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Bisphosphonates affect dental implants

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New research shows bisphosphonates negatively affect success of dental implants for post-menopausal women

Post-menopausal women often suffer from osteoporosis, resulting in a loss of bone mass and strength. To combat this disease, many women take bisphosphonates (BPs) a group of medicines that help slow or prevent bone loss.

However, BP therapy’s effects in terms of successful dental implantation have not been well documented. Dental implantation tends to be highly predicative in terms of effectiveness, but when medication is introduced that will change the overall landscape of the mandible (jawbone) structure, implant failure can be a side-effect.

Researchers from the Kanagawa Dental University Hospital and the Tokyo Medical and Dental University have recently performed a study focused on the use of BP therapy and its effect on the quality of the mandible. The researchers evaluated the bone mineral density and cortical bone thickness (the outer layer bone thickness) of the mandible, as well as how long-term BP therapy affected early implant failure.

This study included 25 female patients, at least 60-years of age, with a previous osteoporosis diagnosis, who underwent dental implant surgery in the mandible between January 2010 and March 2013. The patients were divided into two groups: (1) the BP group consisted of 11 patients who had been taking BPs for more than one year, and (2) the remaining 14 patients were in the non-BP group and had been prescribed a type of hormone therapy.

The patients were compared using several computed tomography (CT) scans of their mandible to gauge bone mineral densities, cortical bone thickness, and the effect that the duration of BP therapy had on these two factors.
The researchers found that in the BP group, 11 patients with a total of 25 implants had three (11.1%) of those implants fail in three (25%) different patients within one year.

In the non-BP group, the 14 patients had a total of 28 implants. Every implant in the non-BP group survived. It was also found that the BP group had a higher bone mineral density than the non-BP group, and those patients with a longer duration of BP therapy had increased cortical bone thickness.

Overall, the researchers believe that BP use is correlated with increased bone mineral density and cortical bone thickness.

The researchers conclude that, “These results indicate that BPs affect the quality and quantity of the cortical bone in the partially edentulous posterior mandible of patients with osteoporosis, which should be considered prior to treatment with dental implants in patients taking BPs.”

This study was limited by both its small population size and the question of whether or not the medications used in the non-BP group had an effect on the mandible as well (which was not tested). However, the researchers have found that BP therapy does impact the mandible, and clinicians should be mindful that remodelling of the mandible could occur in patients receiving BP therapy, prior to beginning implant treatment.

Full text of the article, “Influence of Bisphosphonates on Implant Failure Rates and Characteristics of Postmenopausal Woman Mandibular Jawbone,” Journal of Oral Implantology, Vol. 43, No. 5, 2017, is available, click HERE.

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